Ferroxidase activity of rat ceruloplasmin.
نویسندگان
چکیده
WILLIAMS, ID. M., G. K. LEE, AND G. E CARTWRIGIIT. Fb-roxidasc nctivity of rat ccruloplasmin. Am. J. Physiol. 227(5) : 1094-1097. 1974.-The ferroxidase activity of rat ceruloplasmin was studied under various assay conditions. The ferroxidase activity was optimal at pH 6.0-6.2 in acetate buffer in the absence of ascorbate, and under these conditions the activity was about 1/3rd that of human ceruloplasmin and 1 /lOth that of porcine ceruloplasmin. However, hypoceruloplasmincmic rats developed hypofcrrcmia, and the administration of ceruloplasmin was followed by a prompt increase in plasma iron. Thus, ceruloplasmin appears to be essential for the flow of iron from reticuloendothelial cells to transferrin in the rat as well as the pig.
منابع مشابه
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ورودعنوان ژورنال:
- The American journal of physiology
دوره 227 5 شماره
صفحات -
تاریخ انتشار 1974